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Clinical evidence for Alma platforms
Alma platforms are supported by peer-reviewed clinical research. Explore published studies by platform, with access to each publication, to review the clinical evidence and inform your technology choices.
51 peer-reviewed studies9 platformsAccess to every publication
Platforms
All studies are also available in our Clinical Resources library, searchable by platform and indication.
Reading the clinical evidence. Each entry lists the publication year, authors and journal. Where research was conducted on an earlier Alma platform sharing the same core technology, this is noted in the section summary. Published outcomes reflect controlled study conditions; clinical results vary with patient selection, treatment parameters and operator experience, which is why every Alma Lasers Australia clinic receives protocol-based training.
Alma Soprano (Titanium SE, ICE Platinum, ICE)laser hair removal
Twelve peer-reviewed studies on triple-wavelength and 810 nm diode technology, including five randomised or controlled trials comparing low-fluence in-motion treatment with high-fluence single-pass and Nd:YAG approaches, alongside efficacy and safety data in skin types IV to V.
12 studiesView platform →
- 2023
Novel laser hair removal in all skin types
Michael H. Gold et al. · Journal of Cosmetic Dermatology
- 2022
Three wavelengths integrated: efficacy and safety of a novel combination for hair removal
Pablo Naranjo et al. · Journal of Cosmetic Dermatology
- 2020
A combined triple-wavelength (755 nm, 810 nm and 1064 nm) laser device for hair removal: efficacy and safety study
Lehavit Akerman et al. · Journal of Drugs in Dermatology
- 2021
Efficacy and safety of triple wavelength laser hair reduction in skin types IV to V
E. P. Raj Kirit et al. · Journal of Cosmetic Dermatology
- 2017
Static and dynamic modes of 810 nm diode laser hair removal compared: a clinical and histological study
Tokuya Omi · Laser Therapy
- 2019
Randomized, side-by-side comparison of a topical photo-enhancer gel for hair removal: an efficacy and safety study
Michael H. Gold et al. · Journal of Cosmetic and Laser Therapy
- 2017
Clinical assessment of a new 755 nm diode laser for hair removal: efficacy, safety and practicality in 56 patients
Josefina Royo et al. · Lasers in Surgery and Medicine
- 2009
Permanent laser hair removal with low fluence high repetition rate versus high fluence low repetition rate 810 nm diode laser: a split-leg comparison study
Martin Braun · Journal of Drugs in Dermatology
Randomised, 25 patients: equal 86 to 91% reduction, significantly less pain, the one superficial burn occurred on the high-fluence side
- 2014
A comparison of two 810 nm diode lasers for hair removal: low fluence, multiple pass versus a high fluence, single pass technique
Bonnie Koo, Kaity Ball, Anne-Marie Tremaine, Christopher B. Zachary · Lasers in Surgery and Medicine
Randomised: equal efficacy at 6 and 12 months, pain 2.7 vs 3.6 out of 10
- 2011
Safety and efficacy of low-fluence, high-repetition rate versus high-fluence, low-repetition rate 810 nm diode laser for permanent hair removal: a split-face comparison study
Ganesh S. Pai, Pavritha S. Bhat, Hema Mallya, Michael Gold · Journal of Cosmetic and Laser Therapy
42 women with PCOS hirsutism: 90.5% vs 85% median reduction, low pain score
- 2016
Efficacy of a low fluence, high repetition rate 810 nm diode laser for permanent hair reduction in Indian patients with skin types IV to VI
Madhuri Agarwal, Sangeeta Velaskar, Michael H. Gold · Journal of Clinical and Aesthetic Dermatology
71 patients: complication-free, negligible discomfort
- 2011
A split axilla comparison of low fluence high repetition rate 810 nm diode laser versus high fluence low repetition rate 1064 nm Nd:YAG laser
R. Wanitphakdeedecha et al. · Journal of the European Academy of Dermatology and Venereology
49 subjects: the diode was less painful, the Nd:YAG produced greater axillary hair reduction in this study, included here for balance
Harmony XL Pro and Alma Harmonyskin platform
Clinical evidence across the Harmony applicators, including Dye-VL narrowband light, ClearLift Q-switched Nd:YAG and 1540 nm fractional erbium:glass, covering vascular lesions, photodamage, skin texture, acne scarring and tattoo removal.
12 studiesView platform →
-
Case report: novel leg vein treatment CLaCS guided by augmented reality, 11-year follow-up
Kasuo Miyake, Marcelo Halfen Grill, Heidi Shiho Nagatani Feitoza · Journal of Cosmetic Dermatology
-
Vascular uses of the LP1064 applicator on the Harmony XL Pro device
Christopher N. Nguyen, Michael H. Gold · Journal of Cosmetic Dermatology
- 2023
Effectiveness and safety of a narrow band spectrum intense pulsed-light dye with long pulse Nd:YAG laser for treating facial vascular lesions
Fernando Urdiales-Gálvez, Antonio Castellano-Miralla · Journal of Cosmetic Dermatology
-
Laser treatment of infantile hemangioma
Khamaysi Ziad, Jiryis Badi, Zoabi Roaa, Avitan-Hersh Emily · Journal of Cosmetic Dermatology
- 2018
Treatment of facial telangiectasia with narrowband intense pulsed light
Huihui Gan · Journal of Cosmetic and Laser Therapy
- 2015
Targeted narrowband intense pulsed light on cutaneous vasculature
Wesley J. Moy · Lasers in Surgery and Medicine
- 2022
Visible and quantifiable improvement in skin roughness and texture using a high power non-ablative 1540 nm fractional erbium:glass laser
Pablo Naranjo · Journal of Clinical and Aesthetic Dermatology
- 2020
Face and neck rejuvenation using an improved non-ablative fractional high power 1064 nm Q-switched Nd:YAG laser: clinical results in 16 women
Fernando Urdiales-Gálvez · Journal of Cosmetic and Laser Therapy
- 2019
Erbium and fractional CO₂ lasers in acne scars
Ganesh S. Pai · Journal of Dermatology and Plastic Surgery
- 2016
Split-face comparison between single band and dual band pulsed light technology for treatment of photodamage
Neal Varughese · Journal of Cosmetic and Laser Therapy
- 2019
Cryo-laser and cryo-sclerotherapy guided by augmented reality for telangiectasias, feeder and small varicose vein treatment: the CLaCS technique white paper report
Roberto Kasuo Miyake · Journal of Phlebology and Lymphology
- 2020
Usefulness of high-frequency ultrasound in the monitoring of laser treatment of acne scars
Sylwia Malinowska · Journal of Ultrasonography
Alma HybridCO₂ and 1570 nm resurfacing
Clinical and histological evidence for combined CO₂ and 1570 nm treatment, including periorbital rejuvenation and sequential application. Alma Hybrid, as supplied by Alma Lasers Australia, is included in the ARTG (321320).
3 studiesARTG 321320View platform →
- 2023
The safety and efficacy of a dual CO₂ and 1570 nm hybrid laser for periorbital rejuvenation
Leah Tsur Shenhav, Waseem Shehade, Gerardo Muravnik, Tamir Horovitz, Ofir Artzi · Dermatologic Surgery
- 2022
Clinical and histological evaluation of a dual sequential application of fractional 10,600 nm and 1570 nm lasers, compared to single applications in a porcine model
Igor Snast, Moshe Lapidoth, Assi Levi · Lasers in Medical Science
Alma Pixel CO₂fractional CO₂ resurfacing
Clinical evidence for fractional CO₂ resurfacing, acne scarring, keloid management and laser-assisted drug delivery. Alma Pixel CO₂ is included in the ARTG (323941).
5 studiesARTG 323941View platform →
- 2011
Safe and effective one-session fractional skin resurfacing using a carbon dioxide laser device in super-pulse mode: a clinical and histologic study
Mario A. Trelles · Aesthetic Plastic Surgery
- 2023
Laser combined with radiotherapy for keloid treatment: a novel and efficient comprehensive therapy with a lower recurrence rate
Qian-Yu Ma et al. · Plastic and Reconstructive Surgery
-
Treatment of acne scarring with fractional CO₂ laser
Hui Qian, Zhong Lu, Huilin Ding, Shuxian Yan, Leihong Xiang, Michael H. Gold
- 2021
Comparison of clinical and histologic findings in daylight photodynamic therapy for skin field cancerization: a randomized controlled four-arm study on physical methods-assisted delivery of methyl aminolevulinate
Camila de Oliveira Bento et al. · Photodiagnosis and Photodynamic Therapy
- 2016
Fractional ablative laser followed by transdermal acoustic pressure wave device to enhance the drug delivery of aminolevulinic acid: in vivo fluorescence microscopy study
Jill S. Waibel · Journal of Drugs in Dermatology
Alma PrimeXbody contouring
Clinical evidence for pulsed ultrasound combined with unipolar radiofrequency for non-invasive circumference reduction and body contouring.
2 studiesView platform →
- 2022
Body contouring using a combination of pulsed ultrasound and unipolar radiofrequency: a prospective pilot study
Fernando Urdiales-Gálvez · Aesthetic Plastic Surgery
- 2021
A novel nonfocused pulsed ultrasound technology for noninvasive circumference reduction
Ines Verner · Dermatologic Therapy
Accent Primeradiofrequency and ultrasound
Clinical evidence for radiofrequency and ultrasound, covering lipolysis, skin tightening, cellulite, pore size and non-surgical periorbital tightening.
5 studiesView platform →
- 2017
Use of a novel combined radiofrequency and ultrasound device for lipolysis, skin tightening and cellulite treatment
Rinky Kapoor · Journal of Cosmetic and Laser Therapy
- 2020
A novel ablative radiofrequency microplasma nonsurgical blepharoplasty for dermatochalasis
Ines Verner · Dermatologic Therapy
- 2018
Successful treatment of verrucous epidermal naevus
Xinyao Zheng · Journal of Cosmetic and Laser Therapy
- 2008
Unipolar radiofrequency treatment to improve the appearance of cellulite
Macrene R. Alexiades · Journal of Cosmetic and Laser Therapy
- 2022
Can a radiofrequency device reduce pore size?
Dong Hye Suh · Lasers in Medical Science
Fractional microplasma (Alma Opus)
Fractional microplasma radiofrequency research on scarring, striae and post-burn pigmentation. Several studies were conducted on Alma's earlier microplasma platform, whose core technology is carried forward in Alma Opus.
5 studiesView platform →
- 2017
Fractional microplasma radiofrequency technology for non-hypertrophic post-burn scars in Asians: a prospective study of 95 patients
Shen Wang · Lasers in Surgery and Medicine
- 2015
The use of a fractional ablative micro-plasma radiofrequency device in the treatment of striae
Vineet Mishra · Journal of Drugs in Dermatology
- 2016
Clinical and histological results in the treatment of atrophic and hypertrophic scars using a combined method of radiofrequency, ultrasound and transepidermal drug delivery
Mario A. Trelles · International Journal of Dermatology
- 2012
Transepidermal retinoic acid delivery using ablative fractional radiofrequency associated with acoustic pressure ultrasound for stretch marks treatment
Maria Cláudia Almeida Issa · Lasers in Surgery and Medicine
- 2014
Treatment of facial post-burn hyperpigmentation using micro-plasma radiofrequency technology
Lian-Zhao Wang · Lasers in Medical Science
Alma QQ-switched Nd:YAG
Clinical evidence for Q-switched 1064 nm treatment of post-surgical scarring, hyperpigmentation in skin types IV to V, active acne and non-ablative rejuvenation.
4 studiesView platform →
- 2021
1064 nm Q-switched fractional Nd:YAG laser is safe and effective for the treatment of post-surgical facial scars
Lehavit Akerman et al. · Lasers in Medical Science
- 2020
Q-switched 1064 nm Nd:YAG laser in treating axillary hyperpigmentation in Filipino women with skin types IV to V
Irene Gaile C. Robredo · Journal of Drugs in Dermatology
- 2021
Quasi long-pulsed 1064 nm Nd:YAG (micro pulsed) technology for the treatment of active acne: a case series
Ofir Artzi et al. · Journal of Cosmetic Dermatology
- 2021
A combination of 1064 nm Q-switched fractional Nd:YAG laser with a nonfractional microsecond pulsed technology has a synergistic effect for nonablative facial rejuvenation
Lehavit Akerman et al. · Journal of Cosmetic Dermatology
Alma Duolow-intensity shockwave for erectile dysfunction
Three systematic reviews and meta-analyses of low-intensity extracorporeal shockwave therapy, the technology class to which Alma Duo belongs.
3 studiesView platform →
- 2017
Effects of low-intensity extracorporeal shockwave therapy on erectile dysfunction: a systematic review and meta-analysis
Raul I. Clavijo et al. · The Journal of Sexual Medicine
- 2019
Meta-analysis of randomized controlled trials that assess the efficacy of low-intensity shockwave therapy for the treatment of erectile dysfunction
Jeffrey D. Campbell et al. · Therapeutic Advances in Urology
- 2019
Clinical studies on low intensity extracorporeal shockwave therapy for erectile dysfunction: a systematic review and meta-analysis of randomised controlled trials
Ioannis Sokolakis, Georgios Hatzichristodoulou · International Journal of Impotence Research
Building Australian clinical evidence
Alma Lasers Australia is developing a library of Australian case series in partnership with clinics that share anonymised before-and-after outcomes, reflecting local skin types and sun exposure. To contribute your clinic’s results or request the full text of any study, contact your Alma representative.
Clinical evidence FAQs
Do these studies apply to the devices supplied in Australia?
Most studies were conducted on current Alma platforms. Where research used an earlier platform sharing the same core technology, such as the microplasma studies, this is noted in the relevant section. All devices supplied by Alma Lasers Australia are current models included in the ARTG.
Why do some studies have small sample sizes?
Aesthetic device research typically progresses from pilot and split-face studies to larger clinical series and systematic reviews. This library includes both, reflecting the full evidence base. Your Alma representative can recommend the papers most relevant to your indications.
Is Australian clinical data available?
Australian case series are currently being collected with participating clinics. Alma Academy sessions also share Australian practitioner experience across local skin types.
Further reading
- Questions clinics ask about Alma devicesRunning costs, return on investment and the risks of grey-market imports.
- How to tell a genuine Alma device from a lookalikeWhy published evidence applies only to genuine Alma systems.
- What an aesthetic laser really costs to runConsumables and applicator lifespan, by platform.
The technology behind the clinical evidence
- Soprano in-motion hair removal technologyAlma Soprano
- HyGrid scannerAlma Hybrid
- IMPACT ultrasound
- Pixel RF microplasmaAlma Opus
- UltraWaveAlma PrimeX
- All Alma platformsDevices by category